MassGeneral Institute of Neurodegenerative Disease                                Massachusetts General Hospital   Harvard Medical School

Brian Bacskai Lab - Optical Imaging Approaches for Alzheimer's Disease

Movies

Mpeg Movie1 (1.28 mb)

Flourescent PIB injected i.v. into a Tg2576 mouse.  The fluorescent PIB crosses the Blood Brain Barrier, enters the brain parenchyma, and binds to amyloid plaques and CAA, while the unbound PIB is cleared away.  The time elapsed is ten minutes.  Taken from Bacskai et. al.

Mpeg Movie2 (1.58mb)

3D rendered brain volume of PS1-App mouse.  Plaques were stained with methoxy-XO4.

Mpeg Movie3 (960 kb)

3D reconstruction of distrophic neurites around plaques.  The neurites do not penetrate the plaques but rather curve around them.  Courtesy of Tara Spires, Ph.D.  Spires et. al.

Mpeg Movie4 (619 kb)

In-vivo Imaging of GFP neurons.