MassGeneral Institute of Neurodegenerative Disease                             

  Massachusetts General Hospital

  Harvard Medical School

 

Brian Bacskai Lab - Optical Imaging Approaches for Alzheimer's Disease


 

Selected Publications

Elissa M. Robbins, Rebecca A. Betensky, Sarah B. Domnitz, Susan M. Purcell, Monica Garcia-Alloza, Charles Greenberg, G. William Rebeck, Bradley T. Hyman, Steven M. Greenberg, Matthew P. Frosch, and Brian J. Bacskai. Kinetics of Cerebral Amyloid Angiopathy Progression in a Transgenic Mouse Model of Alzheimer Disease.   Jan. 2006.  Journal of Neuroscience

Kumar AT, Skoch J, Bacskai BJ, Boas DA, Dunn AK. Fluorescence-lifetime-based tomography for turbid media. Opt Lett. 2005 Dec.

Golde TE, Bacskai BJ. Bringing amyloid into focus. Nat Biotechnol. 2005 May

Skoch J, Dunn A, Hyman BT, Bacskai BJ. Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology. J Biomed Opt. 2005 Jan-Feb

Garcia-Alloza M, Bacskai BJ. Techniques for brain imaging in vivo. Neuromolecular Med. 2004

Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT, Holtzman DM. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.
J Clin Invest. 2005 Feb

Stern EA, Bacskai BJ, Hickey GA, Attenello FJ, Lombardo JA, Hyman BT. Synaptic integration in vivo is disrupted by amyloid-beta plaques. J Neurosci. 2004 May

Bacskai BJ, Hickey GA, Skoch J, Kajdasz ST, Wang Y, Huang GF, Mathis CA, Klunk WE, Hyman BT. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice. Proc Natl Acad Sci U S A. 2003 Oct

McLellan ME, Kajdasz ST, Hyman BT, Bacskai BJ. In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy. J Neurosci. 2003 Mar.

Bacskai BJ, Skoch J, Hickey GA, Allen R, Hyman BT. Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques. J Biomed Opt. 2003 Jul

McLellan ME, Kajdasz ST, Hyman BT, Bacskai BJ. In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy. J Neurosci. 2003 Mar

Bacskai BJ, Hyman BT. Alzheimer's disease: what multiphoton microscopy teaches us.
Neuroscientist. 2002 Oct

Bacskai BJ, Kajdasz ST, McLellan ME, Games D, Seubert P, Schenk D, Hyman BT. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.
J Neurosci. 2002 Sep